{"id":80714,"date":"2025-11-06T14:08:26","date_gmt":"2025-11-06T19:08:26","guid":{"rendered":"https:\/\/www.agribusinessglobal.com\/?p=80714"},"modified":"2025-11-10T15:25:40","modified_gmt":"2025-11-10T20:25:40","slug":"accelerating-the-next-generation-of-micropeptide-crop-protection","status":"publish","type":"post","link":"https:\/\/www.agribusinessglobal.com\/es\/agtech\/accelerating-the-next-generation-of-micropeptide-crop-protection\/","title":{"rendered":"Acelerando la pr\u00f3xima generaci\u00f3n de protecci\u00f3n de cultivos con microp\u00e9ptidos"},"content":{"rendered":"
\"\"

Mikael Courbet, Micropep Technologies<\/p><\/div>\n

Ante la creciente presi\u00f3n que enfrenta la agricultura para producir m\u00e1s con menos insumos, la innovaci\u00f3n en la protecci\u00f3n biol\u00f3gica de cultivos avanza a un ritmo sin precedentes. Tecnolog\u00edas Micropep<\/a> est\u00e1 a la vanguardia de esta transformaci\u00f3n con su plataforma de descubrimiento impulsada por IA, Krisalix, dise\u00f1ada para acelerar el desarrollo de biosoluciones basadas en microp\u00e9ptidos. En una conversaci\u00f3n reciente con AgriBusiness Global,<\/strong> Mikael Courbot, director de tecnolog\u00eda de Micropep Technologies, comparti\u00f3 c\u00f3mo la IA est\u00e1 transformando el descubrimiento, ampliando el potencial del dise\u00f1o de p\u00e9ptidos y redefiniendo la forma en que se introducen en el mercado nuevos modos de acci\u00f3n sostenibles.<\/p>\n

Redefiniendo el descubrimiento de la protecci\u00f3n de cultivos mediante la IA<\/strong><\/h2>\n

La inteligencia artificial est\u00e1 abriendo nuevas posibilidades para la velocidad y precisi\u00f3n de los descubrimientos en la protecci\u00f3n de cultivos. Courbot explica que plataformas como Krisalix est\u00e1n transformando todo el proceso de desarrollo al fusionar la IA generativa y predictiva con la biolog\u00eda, la qu\u00edmica y la fabricaci\u00f3n en un sistema unificado.<\/p>\n

\u201cKrisalix permite una transformaci\u00f3n desde el dise\u00f1o de mol\u00e9culas hasta la validaci\u00f3n en laboratorio en tan solo semanas en lugar de meses\u201d, afirma. \u201cEso significa que podemos acelerar los plazos de descubrimiento de nuevos modos de acci\u00f3n en fungicidas, herbicidas e insecticidas\u201d.\u201d<\/p>\n

A diferencia de las herramientas de IA de prop\u00f3sito general centradas en la gen\u00f3mica o la imagen, Krisalix se dise\u00f1\u00f3 espec\u00edficamente para biosoluciones basadas en p\u00e9ptidos. Optimiza el rendimiento de las mol\u00e9culas y, al mismo tiempo, predice su capacidad de fabricaci\u00f3n y estabilidad, capacidades que transforman radicalmente la forma en que se descubren y comercializan los biocontroladores.<\/p>\n

\u201cEsto representa algo m\u00e1s que una simple aceleraci\u00f3n digital\u201d, a\u00f1ade Courbot. \u201cSupone un redise\u00f1o fundamental de c\u00f3mo se crean los futuros sistemas de control biol\u00f3gico\u201d.\u201d<\/p>\n

Ampliando el dise\u00f1o de p\u00e9ptidos m\u00e1s all\u00e1 de los fungicidas<\/strong><\/h2>\n

El primer biofungicida de Micropep, MPD-01, representa la primera validaci\u00f3n importante de la plataforma Krisalix para la empresa, pero esto es solo el comienzo. Courbot prev\u00e9 un futuro mucho m\u00e1s prometedor para el dise\u00f1o de p\u00e9ptidos.<\/p>\n

\u201cGracias a las capacidades de modelado de Krisalix, podemos extender el dise\u00f1o de p\u00e9ptidos mucho m\u00e1s all\u00e1 de los fungicidas y la tecnolog\u00eda de p\u00e9ptidos antimicrobianos\u201d, explica. \u201cEstamos investigando bioherbicidas, biopesticidas e incluso la resiliencia y la nutrici\u00f3n de las plantas\u201d.\u201d<\/p>\n

El motor de cribado virtual de Krisalix puede modelar millones de p\u00e9ptidos candidatos y clasificar los m\u00e1s prometedores seg\u00fan su din\u00e1mica de uni\u00f3n, eficacia y estabilidad. \u201cSolo necesitamos una prote\u00edna diana\u201d, afirma Courbot. \u201cLa plataforma se encarga del resto en cuanto a la generaci\u00f3n de candidatos\u201d.\u201d<\/p>\n

Dado que los p\u00e9ptidos se encuentran de forma natural en todas las plantas y organismos, el mismo marco conceptual puede aplicarse a una amplia gama de desaf\u00edos agr\u00edcolas, desde el estr\u00e9s bi\u00f3tico causado por plagas y pat\u00f3genos hasta el estr\u00e9s abi\u00f3tico como el calor o la sequ\u00eda. Con el tiempo, Courbot prev\u00e9 que Krisalix se convierta en un motor de dise\u00f1o fundamental para insumos agr\u00edcolas sostenibles basados en microp\u00e9ptidos, m\u00e1s seguros, de desarrollo m\u00e1s r\u00e1pido y f\u00e1cilmente adaptables a diferentes cultivos y climas.<\/p>\n

Descubriendo nuevos modos de acci\u00f3n<\/strong><\/h2>\n

Una de las mayores fortalezas de Krisalix reside en su capacidad para ir m\u00e1s all\u00e1 de los modos de acci\u00f3n conocidos y predecir interacciones bioqu\u00edmicas completamente nuevas entre p\u00e9ptidos y sus prote\u00ednas diana. Al combinar la predicci\u00f3n de estructuras proteicas de vanguardia con la generaci\u00f3n de ligandos pept\u00eddicos mediante IA, la plataforma puede simular c\u00f3mo interact\u00faan los p\u00e9ptidos con prote\u00ednas espec\u00edficas para bloquear o modular su funci\u00f3n.<\/p>\n

\u201cEsto nos permite identificar microp\u00e9ptidos en m\u00faltiples tecnolog\u00edas\u201d, dijo Courbot. \u201cEso incluye p\u00e9ptidos antimicrobianos que alteran las membranas f\u00fangicas, bloqueadores de la interacci\u00f3n p\u00e9ptido-prote\u00edna y microp\u00e9ptidos que modulan la traducci\u00f3n gen\u00e9tica\u201d.\u201d<\/p>\n

Este enfoque sistem\u00e1tico es esencial para combatir la resistencia y ampliar la frontera de la eficacia biol\u00f3gica. \u201cAl descubrir nuevos modos de acci\u00f3n\u201d, afirma, \u201cpodemos contribuir a garantizar que la protecci\u00f3n biol\u00f3gica de los cultivos siga evolucionando al ritmo de los cambiantes desaf\u00edos agr\u00edcolas\u201d.\u201d<\/p>\n

Optimizaci\u00f3n de datos para el registro<\/strong><\/h2>\n

La IA no solo acelera los descubrimientos, sino que tambi\u00e9n mejora el rigor y la trazabilidad de los datos que los respaldan. Courbot se\u00f1ala que Krisalix mejora la reproducibilidad y la transparencia en la I+D de p\u00e9ptidos mediante conjuntos de datos centralizados y robustos flujos de trabajo de MLOps que generan paquetes de datos estandarizados y trazables.<\/p>\n

Gracias a la integraci\u00f3n con el motor de conocimiento ADOPT, todos los datos experimentales se centralizan para garantizar la reproducibilidad y facilitar la creaci\u00f3n de expedientes de alta calidad para las presentaciones regulatorias. \u201cDado que los marcos regulatorios para los productos biol\u00f3gicos a\u00fan est\u00e1n en desarrollo, contar con un proceso basado en datos es fundamental\u201d, afirma Courbot. \u201cKrisalix no solo permite la creaci\u00f3n de mejores mol\u00e9culas, sino tambi\u00e9n la integridad y la trazabilidad de los datos que necesitan los organismos reguladores\u201d.\u201d<\/p>\n

Mirando hacia el futuro: La IA como catalizador de la innovaci\u00f3n sostenible<\/strong><\/h2>\n

Para Courbot, el trabajo en Micropep no ha hecho m\u00e1s que empezar. \u201cLos micropeptidos representan una nueva clase de biosoluciones que combinan la precisi\u00f3n de la qu\u00edmica con la sostenibilidad de los productos biol\u00f3gicos\u201d, afirma. \u201cLa r\u00e1pida evoluci\u00f3n de sistemas de IA como Krisalix ha dinamizado el proceso de descubrimiento. Aprendemos constantemente y mejoramos el rendimiento predictivo en cada ciclo\u201d.\u201d<\/p>\n

A medida que se ampl\u00edan las colaboraciones de Micropep con empresas l\u00edderes como Corteva y FMC, Krisalix est\u00e1 preparada para definir una nueva generaci\u00f3n de insumos agr\u00edcolas que se distinguen por su rendimiento, seguridad y escalabilidad.<\/p>\n

\u201cEn definitiva\u201d, concluye Courbot, \u201cla innovaci\u00f3n en p\u00e9ptidos impulsada por la IA har\u00e1 avanzar la agricultura hacia un futuro m\u00e1s productivo, resiliente y sostenible\u201d.\u201d<\/p>","protected":false},"excerpt":{"rendered":"

Micropep Krisalix, impulsado por IA, acelera la protecci\u00f3n biol\u00f3gica de cultivos, impulsando la innovaci\u00f3n sostenible en microp\u00e9ptidos para una agricultura m\u00e1s segura y resiliente.<\/p>","protected":false},"author":1477,"featured_media":80717,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1917,1604,1786],"tags":[54],"class_list":["post-80714","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abg-update-feature","category-agtech","category-biologicals","tag-featured-home"],"yoast_head":"\nAccelerating the Next Generation of Micropeptide Crop Protection - AgriBusiness Global<\/title>\n<meta name=\"description\" content=\"AI-powered Micropep Krisalix accelerates biological crop protection, driving sustainable micropeptide innovation for safer, more resilient agriculture.\" \/>\n<meta name=\"robots\" content=\"index, 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