{"id":58531,"date":"2016-09-13T15:37:43","date_gmt":"2016-09-13T19:37:43","guid":{"rendered":"https:\/\/www.agribusinessglobal.com\/?p=58531"},"modified":"2019-09-25T06:31:28","modified_gmt":"2019-09-25T10:31:28","slug":"syngentas-scientists-adjust-to-changing-practices","status":"publish","type":"post","link":"https:\/\/www.agribusinessglobal.com\/pt\/agrochemicals\/syngentas-scientists-adjust-to-changing-practices\/","title":{"rendered":"Cientistas da Syngenta se adaptam \u00e0s mudan\u00e7as de pr\u00e1ticas"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-58532\" src=\"https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--300x200.jpg\" alt=\"syn-formulations\" width=\"300\" height=\"200\" srcset=\"https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--300x200.jpg 300w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--768x512.jpg 768w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--330x220.jpg 330w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--108x72.jpg 108w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--540x360.jpg 540w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--864x576.jpg 864w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--85x57.jpg 85w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations--150x100.jpg 150w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-.jpg 960w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>O tempo e o custo para descobrir um ingrediente ativo, desenvolver uma formula\u00e7\u00e3o adequada e entregar um novo produto de prote\u00e7\u00e3o de cultivo ao mercado aumentaram significativamente na \u00faltima d\u00e9cada. As estimativas colocam os n\u00fameros em mais de 11 anos e mais de $250 milh\u00f5es.<br \/>\nN\u00e3o \u00e9 de se surpreender, ent\u00e3o, que empresas como a Syngenta acompanhem esses esfor\u00e7os com a reformula\u00e7\u00e3o de produtos existentes.<br \/>\nH\u00e1 uma s\u00e9rie de raz\u00f5es pelas quais as empresas decidem reformular produtos existentes: melhorar a efic\u00e1cia, dar suporte a estrat\u00e9gias de gerenciamento de resist\u00eancia, garantir propriedade intelectual, preocupa\u00e7\u00f5es regulat\u00f3rias e se adaptar \u00e0s pr\u00e1ticas de mudan\u00e7a dos produtores, s\u00f3 para citar algumas.<br \/>\nSeja qual for o motivo, reformular a tecnologia existente ajuda a prolongar a vida \u00fatil de uma IA, o que ajuda as empresas a recuperar esse investimento de tempo e dinheiro.<br \/>\n\u201cO caminho para levar uma mol\u00e9cula da descoberta ao mercado \u00e9 longo e caro\u201d, diz Matthew Cottle, Ph.D., L\u00edder de Grupo, Desenvolvimento de Formula\u00e7\u00e3o de Herbicidas, Syngenta. \u201cO Desenvolvimento de Formula\u00e7\u00e3o se envolve cedo para identificar quaisquer bloqueadores para entregar um produto de qualidade.\u201d<br \/>\nCottle e sua equipe ajudam a desenvolver formula\u00e7\u00f5es tanto para novas mol\u00e9culas no pipeline de desenvolvimento quanto para reformula\u00e7\u00f5es de tecnologias existentes.<br \/>\n\u201cH\u00e1 vari\u00e1veis que devem ser consideradas antes que as mol\u00e9culas possam ser identificadas como o pr\u00f3ximo herbicida ou fungicida\u201d, ele diz. \u201cUma vez que chegamos a esse ponto, gastamos muito dinheiro e tempo no lado de P&amp;D, observando seu perfil.\u201d<\/p>\n<div id=\"attachment_58534\" style=\"width: 224px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-58534\" class=\"size-medium wp-image-58534\" src=\"https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-214x300.jpg\" alt=\"Dr. Matthew Cottle, Group Leader, Herbicide  Formulation Development, Syngenta\" width=\"214\" height=\"300\" srcset=\"https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-214x300.jpg 214w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-236x330.jpg 236w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-51x72.jpg 51w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-257x360.jpg 257w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-411x576.jpg 411w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-61x85.jpg 61w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-290x406.jpg 290w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823-145x203.jpg 145w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9823.jpg 457w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><p id=\"caption-attachment-58534\" class=\"wp-caption-text\">Dr. Matthew Cottle, L\u00edder de Grupo, Desenvolvimento de Formula\u00e7\u00e3o de Herbicidas, Syngenta<\/p><\/div>\n<p><strong>Falhe r\u00e1pido, falhe barato<\/strong><br \/>\nDito isso, a equipe de desenvolvimento de formula\u00e7\u00e3o gosta de \u201cconstruir informa\u00e7\u00f5es de formula\u00e7\u00e3o no processo de P&amp;D o mais cedo poss\u00edvel\u201d, diz Cottle. \u201cDescobrimos quais tipos de formula\u00e7\u00e3o s\u00e3o apropriados para uma determinada mol\u00e9cula. Ela \u00e9 sol\u00favel em solventes; precisa ser uma formula\u00e7\u00e3o seca; tem algum problema com estabilidade em \u00e1gua? Quando estamos desenvolvendo um produto a s\u00e9rio, temos algumas informa\u00e7\u00f5es b\u00e1sicas sobre ele.<br \/>\nIsso nos permite entregar produtos em tempo h\u00e1bil.\u201d<br \/>\nEssa abordagem tem outro efeito.<\/p>\n<p>\u201cTendemos a nos envolver em est\u00e1gios mais iniciais do ciclo de vida de um ingrediente ativo do que era costumeiro anos atr\u00e1s\u201d, diz Andrew Pearson, Syngenta, Formulation and Analytical Development Manager para a Am\u00e9rica do Norte. \u201cSe voc\u00ea vai fracassar, voc\u00ea quer fracassar r\u00e1pido e fracassar barato. Quanto mais cedo voc\u00ea souber que algo n\u00e3o vai funcionar, mais cedo voc\u00ea pode parar as avalia\u00e7\u00f5es antes que estudos caros sejam iniciados.\u201d<br \/>\nUma mol\u00e9cula n\u00e3o \u00e9 mais testada passo a passo, esperando para ver se passa antes de passar para a pr\u00f3xima fase de desenvolvimento.<br \/>\n\u201cQuanto mais voc\u00ea puder fazer essas atividades em paralelo, voc\u00ea pode come\u00e7ar a tentar reduzir os 11 anos e economizar tempo e dinheiro\u201d, diz Pearson. \u201cVoc\u00ea corre um pouco mais de risco ao investir recursos de formula\u00e7\u00e3o mais cedo na pesquisa.\u201d<br \/>\nAl\u00e9m de onde uma mol\u00e9cula est\u00e1 no pipeline, o n\u00famero de produtos nesse pipeline influencia o grupo de formula\u00e7\u00e3o, diz Pearson.<br \/>\n\u201cCinco anos atr\u00e1s, est\u00e1vamos mais focados em estender o portf\u00f3lio de IA existente\u201d, ele diz. No in\u00edcio deste ano, a Syngenta anunciou que entregaria 16 novos produtos ao mercado.<br \/>\n\u201cN\u00f3s adaptamos nossos recursos de formula\u00e7\u00e3o para dar suporte ao atual pipeline de P&amp;D\u201d, diz Pearson.<\/p>\n<p><strong>Reformula\u00e7\u00f5es<\/strong><br \/>\nOs produtos s\u00e3o rigorosamente testados em diversas condi\u00e7\u00f5es, mas mesmo assim, eles podem voltar para o grupo de formula\u00e7\u00e3o.<br \/>\n\u201cSempre fazemos o melhor para n\u00e3o ter problemas quando vamos ao mercado, mas mudan\u00e7as nas pr\u00e1ticas de uso ou circunst\u00e2ncias imprevistas podem exigir que recuemos e fa\u00e7amos algumas mudan\u00e7as que, esperan\u00e7osamente, forne\u00e7am algum benef\u00edcio ao cliente\u201d, diz Cottle.<br \/>\nA quantidade de trabalho feito na reformula\u00e7\u00e3o de um produto realmente depende do motivo pelo qual ele est\u00e1 sendo reformulado em primeiro lugar. Tamb\u00e9m pode afetar a avalia\u00e7\u00e3o que um produto recebe quando passa pelo processo de novo registro.<br \/>\n\u201cTemos projetos de reformula\u00e7\u00e3o que envolvem apenas pequenos ajustes na composi\u00e7\u00e3o: por exemplo, a otimiza\u00e7\u00e3o de um auxiliar de suspens\u00e3o\u201d, diz Cottle. \u201cEsses tipos de formula\u00e7\u00f5es alternativas podem frequentemente progredir mais rapidamente por meio da aprova\u00e7\u00e3o regulat\u00f3ria na EPA.\u201d<br \/>\nAs pr\u00e9-misturas fornecem uma variedade de benef\u00edcios tanto para o cliente quanto para a empresa. As pr\u00e9-misturas simplificam a tecnologia para o produtor, diz Pearson. \u201cH\u00e1 menos mistura de tanque que os produtores precisam fazer no local quando est\u00e3o aplicando produtos pr\u00e9-misturados.\u201d<br \/>\nOutra vantagem das pr\u00e9-misturas, diz Pearson, \u00e9 o impulso que elas oferecem \u00e0s estrat\u00e9gias de gerenciamento de resist\u00eancia.<\/p>\n<div id=\"attachment_58533\" style=\"width: 224px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-58533\" class=\"size-medium wp-image-58533\" src=\"https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-214x300.jpg\" alt=\"Andrew Pearson, Syngenta, Formulation and Analytical Development Manager for North America\" width=\"214\" height=\"300\" srcset=\"https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-214x300.jpg 214w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-236x330.jpg 236w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-51x72.jpg 51w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-257x360.jpg 257w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-411x576.jpg 411w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-61x85.jpg 61w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-290x406.jpg 290w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797-145x203.jpg 145w, https:\/\/d6kq167ddwbdq.cloudfront.net\/farmchemint\/wp-content\/uploads\/2016\/09\/Syn.Formulations-9797.jpg 457w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><p id=\"caption-attachment-58533\" class=\"wp-caption-text\">Andrew Pearson, Syngenta, Gerente de Formula\u00e7\u00e3o e Desenvolvimento Anal\u00edtico para a Am\u00e9rica do Norte<\/p><\/div>\n<p><strong>Previs\u00e3o regulat\u00f3ria<\/strong><br \/>\nAs responsabilidades no grupo de tecnologia de formula\u00e7\u00e3o n\u00e3o s\u00e3o apenas sobre a ci\u00eancia. &quot;A previs\u00e3o regulat\u00f3ria \u00e9 um grande desafio&quot;, diz Pearson.<br \/>\nA empresa faz o melhor que pode para prever como ser\u00e1 o ambiente regulat\u00f3rio nos pr\u00f3ximos anos e o impacto que isso ter\u00e1 em suas formula\u00e7\u00f5es. A empresa mant\u00e9m um controle rigoroso sobre as regras e regulamenta\u00e7\u00f5es desenvolvidas por governos ao redor do mundo.<br \/>\n\u201cSe virmos certos produtos qu\u00edmicos com alto risco de press\u00e3o regulat\u00f3ria futura, podemos tomar a decis\u00e3o de reformular proativamente os produtos que cont\u00eam essa IA\u201d, diz Pearson.<br \/>\nOs cientistas da Syngenta est\u00e3o sempre buscando avan\u00e7ar em dire\u00e7\u00e3o a uma qu\u00edmica mais segura.<br \/>\n\u201cConstantemente falamos sobre como podemos ter melhor previs\u00e3o regulat\u00f3ria\u201d, diz Pearson. \u201cRevisamos documentos da EPA e olhamos literatura e artigos de outros pa\u00edses. Tentamos acompanhar isso em uma base global, e as decis\u00f5es sobre usar ou n\u00e3o produtos qu\u00edmicos espec\u00edficos s\u00e3o um grande desafio.\u201d<\/p>\n<p>Entre em contato com Dan: <a href=\"mailto:djacobs@meistermedia.com\" target=\"_blank\" rel=\"noopener noreferrer\">djacobs@meistermedia.com<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>O tempo e o custo para descobrir um ingrediente ativo, desenvolver uma formula\u00e7\u00e3o adequada e entregar um novo produto de prote\u00e7\u00e3o de cultivos\u2026<\/p>","protected":false},"author":112,"featured_media":58532,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4,18,19,20],"tags":[554,54,121],"class_list":["post-58531","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agrochemicals","category-fungicides","category-herbicides","category-insecticides","tag-featured","tag-featured-home","tag-syngenta"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Syngenta\u2019s Scientists Adjust to Changing Practices - AgriBusiness Global<\/title>\n<meta name=\"description\" content=\"The time and cost to discover an active ingredient, develop a suitable formulation, and deliver a new crop protection product to market have increased\" \/>\n<meta name=\"robots\" content=\"index, follow, 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