{"id":67579,"date":"2021-06-22T15:47:09","date_gmt":"2021-06-22T19:47:09","guid":{"rendered":"https:\/\/www.agribusinessglobal.com\/?p=67579"},"modified":"2021-07-12T10:31:59","modified_gmt":"2021-07-12T14:31:59","slug":"syngenta-partners-with-enko-to-accelerate-molecule-discovery","status":"publish","type":"post","link":"https:\/\/www.agribusinessglobal.com\/pt\/agrochemicals\/syngenta-partners-with-enko-to-accelerate-molecule-discovery\/","title":{"rendered":"Syngenta faz parceria com Enko para acelerar a descoberta de mol\u00e9culas"},"content":{"rendered":"
\"Enko

Pesquisadores da Enko avaliam novo controle de pragas no milho. Cr\u00e9dito da foto: Tim Llewellyn<\/p><\/div>\n

Pela segunda vez neste ano, a Syngenta fez parceria com uma empresa de pesquisa que utiliza novas t\u00e9cnicas de descoberta de mol\u00e9culas usadas no desenvolvimento farmac\u00eautico para levar novas IAs ao mercado para a agricultura.<\/p>\n

Empresa de sa\u00fade de cultivos Enko<\/a> e a Syngenta anunciaram hoje uma parceria de v\u00e1rios anos para atingir pragas espec\u00edficas e projetar novas mol\u00e9culas para control\u00e1-las. As empresas ainda est\u00e3o identificando conjuntamente projetos priorit\u00e1rios, e novos herbicidas para combater ervas daninhas resistentes em milho e soja nas Am\u00e9ricas podem ser os primeiros alvos prov\u00e1veis.<\/p>\n

Veja como funciona:<\/p>\n

\"Aerial<\/a>

Vista a\u00e9rea da sede da Enko em Mystic, Connecticut.<\/p><\/div>\n

A abordagem baseada em alvos da Enko combina novas tecnologias de descoberta de medicamentos, como bibliotecas codificadas por DNA, com aprendizado de m\u00e1quina e biologia estrutural para melhorar drasticamente a escala e a velocidade da P&D de prote\u00e7\u00e3o de cultivos. A abordagem permite que os cientistas examinem mais de 120 bilh\u00f5es de compostos simultaneamente para identificar mol\u00e9culas que se ligam como uma fechadura e chave a variantes enzim\u00e1ticas espec\u00edficas em pragas. Essas mol\u00e9culas altamente seletivas s\u00e3o mais eficazes em quantidades menores e n\u00e3o impactam variantes enzim\u00e1ticas semelhantes em outros organismos, o que estabelece barreiras de seguran\u00e7a desde a primeira etapa da descoberta.<\/p>\n

O aprendizado de m\u00e1quina permite que a Enko combine compostos que podem ser eficazes no controle de uma praga alvo usando novos caminhos, ao mesmo tempo em que rastreia esse composto para toxicidade ambiental e n\u00e3o alvo. Ele pode ent\u00e3o projetar um caminho de origem e formula\u00e7\u00e3o. O processo pode reduzir o cronograma de P&D pela metade, de acordo com a Enko.<\/p>\n

\u201cTemos 120 bilh\u00f5es de compostos em nossa biblioteca, levaria muitas vidas para avali\u00e1-los usando m\u00e9todos tradicionais\u201d, disse a CEO da Enko, Jacqueline Heard. Agroneg\u00f3cio Global<\/em>. Estamos encontrando os pontos de partida e levando a modelagem e a IA de l\u00e1 para projetar compostos como uma fechadura e uma chave para alavancar a modelagem e o design baseado em estrutura para descobrir novas mat\u00e9rias qu\u00edmicas.\u201d<\/p>\n

Syngenta assinou um acordo semelhante com a Insilico Medicine<\/a> em fevereiro, ilustrando o foco e o investimento da Syngenta em produtos de prote\u00e7\u00e3o de cultivos de \u00faltima gera\u00e7\u00e3o usando aprendizado de m\u00e1quina para descobrir novos caminhos para o controle de pragas.<\/p>\n

\"Jacqueline

Jacqueline Heard, CEO da Enko<\/p><\/div>\n

Espera-se que os acordos gerem mais produtos novos do que os que est\u00e3o sendo lan\u00e7ados anualmente, e eles ser\u00e3o lan\u00e7ados no mercado mais rapidamente, diz Heard.<\/p>\n

\u201cEm nosso pr\u00f3prio processo de descoberta, come\u00e7amos com alguns novos alvos e produtos qu\u00edmicos herbicidas, ent\u00e3o, em 2 a 5 anos, definitivamente teremos mol\u00e9culas em comercializa\u00e7\u00e3o e teremos uma estrat\u00e9gia de comercializa\u00e7\u00e3o mais frequente daqui para frente\u201d, disse ela.<\/p>\n

A capacidade de atingir pragas espec\u00edficas e projetar novas mol\u00e9culas para control\u00e1-las de forma mais eficiente pode reduzir o custo do desenvolvimento, o que pode tornar os produtos para economias em desenvolvimento mais acess\u00edveis tanto para fabricantes quanto para fazendas. Em seu comunicado \u00e0 imprensa, a Enko diz que a perspectiva de op\u00e7\u00f5es acess\u00edveis e solu\u00e7\u00f5es mais eficientes para tratar pragas e novas doen\u00e7as beneficiar\u00e1 dramaticamente os agricultores em todo o mundo. Em particular, a Enko est\u00e1 comprometida em desenvolver produtos de sa\u00fade de safras acess\u00edveis para pequenos agricultores na \u00c1frica, Am\u00e9rica do Sul e \u00c1sia, que enfrentam uma desvantagem desproporcional de pragas devido \u00e0s mudan\u00e7as clim\u00e1ticas e s\u00e3o mal atendidos pelos produtos no mercado hoje.<\/p>\n

A Syngenta, com suas redes de distribui\u00e7\u00e3o ao redor do mundo, liderar\u00e1 a comercializa\u00e7\u00e3o dos produtos desenvolvidos em conjunto pela Enko.<\/p>","protected":false},"excerpt":{"rendered":"

Empresas desenvolver\u00e3o em conjunto novos produtos qu\u00edmicos usando IA para combater press\u00f5es espec\u00edficas de pragas.<\/p>","protected":false},"author":14,"featured_media":67580,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4,1849],"tags":[54],"class_list":["post-67579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agrochemicals","category-sourcing-insider","tag-featured-home"],"yoast_head":"\nSyngenta Partners with Enko to Accelerate Molecule Discovery - AgriBusiness Global<\/title>\n<meta name=\"description\" content=\"Companies to co-develop novel chemistries using AI to target specific pest pressures.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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