{"id":69143,"date":"2022-06-14T11:00:31","date_gmt":"2022-06-14T15:00:31","guid":{"rendered":"https:\/\/www.agribusinessglobal.com\/?p=69143"},"modified":"2022-06-14T11:00:31","modified_gmt":"2022-06-14T15:00:31","slug":"enko-advances-enkompass-platform-through-dna-encoded-library-technology-enablement-from-x-chem","status":"publish","type":"post","link":"https:\/\/www.agribusinessglobal.com\/pt\/plant-health\/enko-advances-enkompass-platform-through-dna-encoded-library-technology-enablement-from-x-chem\/","title":{"rendered":"Enko avan\u00e7a plataforma Enkompass por meio da tecnologia de biblioteca codificada por DNA da X-Chem"},"content":{"rendered":"

Enko<\/a>, a empresa de sa\u00fade de safras, anunciou a aquisi\u00e7\u00e3o de bibliotecas propriet\u00e1rias codificadas por DNA e habilita\u00e7\u00e3o de tecnologia da empresa l\u00edder em servi\u00e7os de descoberta de medicamentos X-Qu\u00edmica<\/a>. A Enko \u00e9 a primeira empresa a internalizar essa tecnologia para aplica\u00e7\u00f5es agr\u00edcolas. As bibliotecas ajudar\u00e3o a acelerar a descoberta e o desenvolvimento de solu\u00e7\u00f5es de prote\u00e7\u00e3o de cultivos seguras e sustent\u00e1veis, urgentemente necess\u00e1rias aos agricultores.<\/p>\n

Bibliotecas codificadas por DNA s\u00e3o uma ferramenta comprovada para dar in\u00edcio a projetos de descoberta de medicamentos farmac\u00eauticos devido \u00e0 efici\u00eancia da triagem de espa\u00e7os qu\u00edmicos amplos e diversos. A Enko foi pioneira na aplica\u00e7\u00e3o dessa abordagem para enfrentar os desafios da agricultura. Esta aquisi\u00e7\u00e3o \u00e9 um avan\u00e7o significativo para a plataforma ENKOMPASS da Enko, que combina triagem de bibliotecas codificadas por DNA com aprendizado de m\u00e1quina e design baseado em estrutura para encontrar qu\u00edmica inovadora e novos modos de a\u00e7\u00e3o para controlar pragas e doen\u00e7as de planta\u00e7\u00f5es. O m\u00e9todo de descoberta direcionada da Enko descobre pontos de partida qu\u00edmicos promissores em meses, em compara\u00e7\u00e3o aos anos que leva para abordagens tradicionais de P&D.<\/p>\n

\u201cA diversidade \u00e9 a base e o bloco de constru\u00e7\u00e3o essencial para a inova\u00e7\u00e3o no espa\u00e7o de design de medicamentos, e nossos agricultores precisam disso mais do que nunca\u201d, disse a CEO e fundadora da Enko, Jacqueline Heard. \u201cPossuir essas bibliotecas da X-Chem nos d\u00e1 mais flexibilidade para explorar o universo qu\u00edmico e prever qual mol\u00e9cula ser\u00e1 a certa para uma amea\u00e7a espec\u00edfica \u00e0 cultura. Por exemplo, podemos ajustar nossas telas para focar em uma nova estrutura que tem como alvo enzimas de insetos-praga sem prejudicar as abelhas. Isso \u00e9 semelhante a como os pesquisadores adaptaram medicamentos contra o c\u00e2ncer para matar c\u00e9lulas cancer\u00edgenas sem afetar outras.\u201d<\/p>\n

O pareamento da triagem de biblioteca codificada por DNA com aprendizado de m\u00e1quina permite que a Enko explore novos espa\u00e7os qu\u00edmicos, o que \u00e9 essencial para superar a resist\u00eancia generalizada de pragas. Com essas novas bibliotecas, cada experimento produzir\u00e1 pontos de partida moleculares de alta qualidade e dados de treinamento para modelos de aprendizado de m\u00e1quina que aumentam a efici\u00eancia da gera\u00e7\u00e3o de hits e otimiza\u00e7\u00e3o de leads. Para descobrir novos modos de a\u00e7\u00e3o seguros e eficazes para pragas, a Enko pode rastrear bilh\u00f5es de mol\u00e9culas dentro de suas bibliotecas codificadas por DNA e usar intelig\u00eancia artificial e aprendizado de m\u00e1quina para criar maneiras mais eficazes de encontrar e selecionar os tratamentos certos para os alvos certos, mais r\u00e1pido do que qualquer um jamais imaginou ser poss\u00edvel.<\/p>\n

\u201cO universo de produtos qu\u00edmicos que podem ser minerados para produtos seguros e eficazes para a sa\u00fade das planta\u00e7\u00f5es \u00e9 enorme. At\u00e9 agora, os pesquisadores mal arranharam sua superf\u00edcie\u201d, disse Noor Shaker, vice-presidente s\u00eanior da X-Chem e membro do conselho da Enko. \u201cSomos campe\u00f5es da descoberta de medicamentos baseada em DEL, e nosso trabalho com a Enko mostrou a ampla aplica\u00e7\u00e3o dessa tecnologia para impulsionar pipelines de produtos mais direcionados em produtos farmac\u00eauticos e agr\u00edcolas.\u201d<\/p>\n

Esta aquisi\u00e7\u00e3o de tecnologia segue um ano em que a Enko fez parceria com tr\u00eas das maiores empresas agr\u00edcolas do mundo \u2013 Bayer, Syngenta e Nufarm. A Enko teve uma taxa de sucesso muito forte com seu programa DEL, produzindo novos pontos de partida moleculares em v\u00e1rios alvos de pragas para combater ervas daninhas, fungos, insetos e parasitas do solo. A abordagem da empresa ganhou o reconhecimento do F\u00f3rum Econ\u00f4mico Mundial como Pioneira em Tecnologia de 2021.<\/p>","protected":false},"excerpt":{"rendered":"

Grandes conjuntos de dados treinar\u00e3o modelos de aprendizado de m\u00e1quina e acelerar\u00e3o a descoberta \u00e1gil de novas solu\u00e7\u00f5es de prote\u00e7\u00e3o de cultivos.<\/p>","protected":false},"author":110,"featured_media":60768,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[926,1849],"tags":[],"class_list":["post-69143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-plant-health","category-sourcing-insider"],"yoast_head":"\nEnko Advances Enkompass Platform Through DNA-encoded Library Technology Enablement from X-Chem - AgriBusiness Global<\/title>\n<meta name=\"description\" content=\"Large datasets will train machine learning models and speed up agile discovery of novel crop protection solutions.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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