{"id":80714,"date":"2025-11-06T14:08:26","date_gmt":"2025-11-06T19:08:26","guid":{"rendered":"https:\/\/www.agribusinessglobal.com\/?p=80714"},"modified":"2025-11-10T15:25:40","modified_gmt":"2025-11-10T20:25:40","slug":"accelerating-the-next-generation-of-micropeptide-crop-protection","status":"publish","type":"post","link":"https:\/\/www.agribusinessglobal.com\/pt\/agtech\/accelerating-the-next-generation-of-micropeptide-crop-protection\/","title":{"rendered":"Acelerar a pr\u00f3xima gera\u00e7\u00e3o de prote\u00e7\u00e3o de culturas com micropept\u00eddeos"},"content":{"rendered":"
\"\"

Mikael Courbet, Micropep Technologies<\/p><\/div>\n

Com a agricultura enfrentando uma press\u00e3o crescente para produzir mais com menos insumos, a inova\u00e7\u00e3o na prote\u00e7\u00e3o biol\u00f3gica de cultivos est\u00e1 avan\u00e7ando em um ritmo sem precedentes. Tecnologias Micropep<\/a> est\u00e1 na vanguarda dessa transforma\u00e7\u00e3o com sua plataforma de descoberta baseada em IA, Krisalix, projetada para acelerar o desenvolvimento de biossolu\u00e7\u00f5es \u00e0 base de micropept\u00eddeos. Em uma conversa recente com Agroneg\u00f3cio Global,<\/strong> Mikael Courbot, Diretor de Tecnologia da Micropep Technologies, compartilhou como a IA est\u00e1 remodelando a descoberta, expandindo o potencial do design de pept\u00eddeos e redefinindo a forma como novos modos de a\u00e7\u00e3o sustent\u00e1veis s\u00e3o levados ao mercado.<\/p>\n

Reformulando a descoberta de prote\u00e7\u00e3o de cultivos por meio da IA<\/strong><\/h2>\n

A intelig\u00eancia artificial est\u00e1 abrindo novas possibilidades para a velocidade e precis\u00e3o das descobertas na prote\u00e7\u00e3o de cultivos. Courbot explica que plataformas como a Krisalix est\u00e3o transformando todo o processo de desenvolvimento, integrando IA generativa e preditiva com biologia, qu\u00edmica e manufatura em um sistema unificado.<\/p>\n

\u201cO Krisalix permite uma transforma\u00e7\u00e3o do design da mol\u00e9cula \u00e0 valida\u00e7\u00e3o em laborat\u00f3rio em apenas semanas, em vez de meses\u201d, afirma. \u201cIsso significa que podemos acelerar os prazos de descoberta de novos modos de a\u00e7\u00e3o para fungicidas, herbicidas e inseticidas.\u201d<\/p>\n

Ao contr\u00e1rio das ferramentas de IA de uso geral focadas em gen\u00f4mica ou imagem, o Krisalix foi desenvolvido especificamente para biossolu\u00e7\u00f5es \u00e0 base de pept\u00eddeos. Ele otimiza o desempenho das mol\u00e9culas, al\u00e9m de prever a capacidade de fabrica\u00e7\u00e3o e a estabilidade, capacidades que mudam fundamentalmente a forma como os biocontroladores s\u00e3o descobertos e levados ao mercado.<\/p>\n

\u201cIsso representa mais do que apenas uma acelera\u00e7\u00e3o digital\u201d, acrescenta Courbot. \u201cRepresenta uma reformula\u00e7\u00e3o fundamental de como os futuros biocontroles ser\u00e3o criados.\u201d<\/p>\n

Expandindo o design de pept\u00eddeos para al\u00e9m dos fungicidas<\/strong><\/h2>\n

O primeiro biofungicida da Micropep, o MPD-01, representa a primeira grande valida\u00e7\u00e3o da plataforma Krisalix pela empresa, mas \u00e9 apenas o come\u00e7o. Courbot vislumbra um futuro muito mais amplo para o design de pept\u00eddeos.<\/p>\n

\u201cCom os recursos de modelagem da Krisalix, podemos expandir o design de pept\u00eddeos muito al\u00e9m de fungicidas e tecnologia de pept\u00eddeos antimicrobianos\u201d, explica ele. \u201cEstamos explorando bioherbicidas, biopesticidas e at\u00e9 mesmo resili\u00eancia e nutri\u00e7\u00e3o de plantas.\u201d<\/p>\n

O mecanismo de triagem virtual da Krisalix consegue modelar milh\u00f5es de candidatos a pept\u00eddeos e classificar os mais promissores com base na din\u00e2mica de liga\u00e7\u00e3o, efic\u00e1cia e estabilidade. "Tudo o que precisamos \u00e9 de uma prote\u00edna-alvo", diz Courbot. "A plataforma faz o resto em termos de gera\u00e7\u00e3o de compostos l\u00edderes."\u201c<\/p>\n

Como os pept\u00eddeos ocorrem naturalmente em todas as plantas e organismos, a mesma estrutura pode ser aplicada a uma ampla gama de desafios agr\u00edcolas, desde o estresse bi\u00f3tico causado por pragas e pat\u00f3genos at\u00e9 o estresse abi\u00f3tico, como calor ou seca. Com o tempo, Courbot espera que a Krisalix se torne um mecanismo central de design para insumos agr\u00edcolas sustent\u00e1veis \u00e0 base de micropept\u00eddeos, que sejam mais seguros, mais r\u00e1pidos de desenvolver e facilmente adapt\u00e1veis a diferentes culturas e climas.<\/p>\n

Descobrindo novos modos de a\u00e7\u00e3o<\/strong><\/h2>\n

Um dos maiores trunfos da Krisalix reside na sua capacidade de ir al\u00e9m dos modos de a\u00e7\u00e3o conhecidos e prever intera\u00e7\u00f5es bioqu\u00edmicas totalmente novas entre pept\u00eddeos e seus alvos proteicos. Ao combinar a predi\u00e7\u00e3o de estrutura proteica de \u00faltima gera\u00e7\u00e3o com a gera\u00e7\u00e3o de ligantes pept\u00eddicos baseada em IA, a plataforma consegue simular como os pept\u00eddeos interagem com prote\u00ednas espec\u00edficas para bloquear ou modular sua fun\u00e7\u00e3o.<\/p>\n

\u201cIsso nos permite identificar micropept\u00eddeos em m\u00faltiplas tecnologias\u201d, disse Courbot. \u201cIsso inclui pept\u00eddeos antimicrobianos que rompem as membranas f\u00fangicas, bloqueadores de intera\u00e7\u00e3o pept\u00eddeo-prote\u00edna e micropept\u00eddeos que modulam a tradu\u00e7\u00e3o g\u00eanica.\u201d<\/p>\n

Essa abordagem sistem\u00e1tica \u00e9 essencial para combater a resist\u00eancia e expandir a fronteira da efic\u00e1cia biol\u00f3gica. "Ao descobrirmos novos modos de a\u00e7\u00e3o", afirma ele, "podemos ajudar a garantir que a prote\u00e7\u00e3o biol\u00f3gica de cultivos continue a evoluir acompanhando os desafios agr\u00edcolas em constante mudan\u00e7a."\u201c<\/p>\n

Simplifica\u00e7\u00e3o dos dados para o cadastro<\/strong><\/h2>\n

A IA n\u00e3o apenas acelera as descobertas: ela tamb\u00e9m aprimora o rigor e a rastreabilidade dos dados subjacentes. Courbot observa que a Krisalix aumenta a reprodutibilidade e a transpar\u00eancia na P&D de pept\u00eddeos por meio de conjuntos de dados centralizados e pipelines robustos de MLOps que geram pacotes de dados padronizados e rastre\u00e1veis.<\/p>\n

Por meio da integra\u00e7\u00e3o com o ADOPT Knowledge Engine, todos os dados experimentais s\u00e3o centralizados para garantir a reprodutibilidade e apoiar a cria\u00e7\u00e3o de dossi\u00eas de alta qualidade para submiss\u00f5es regulat\u00f3rias. "Considerando que as estruturas regulat\u00f3rias para produtos biol\u00f3gicos ainda est\u00e3o em evolu\u00e7\u00e3o, ter um processo orientado por dados \u00e9 crucial", afirma Courbot. "O Krisalix n\u00e3o s\u00f3 possibilita a cria\u00e7\u00e3o de mol\u00e9culas melhores, como tamb\u00e9m a integridade e a rastreabilidade dos dados que os \u00f3rg\u00e3os reguladores exigem."\u201c<\/p>\n

Olhando para o futuro: a IA como catalisadora da inova\u00e7\u00e3o sustent\u00e1vel.<\/strong><\/h2>\n

Para Courbot, o trabalho na Micropep est\u00e1 apenas come\u00e7ando. \u201cOs micropept\u00eddeos representam uma nova classe de biossolu\u00e7\u00f5es que combinam a precis\u00e3o da qu\u00edmica com a sustentabilidade dos produtos biol\u00f3gicos\u201d, afirma. \u201cA r\u00e1pida evolu\u00e7\u00e3o de sistemas de IA como o Krisalix tornou o processo de descoberta din\u00e2mico. Estamos constantemente aprendendo e aprimorando o desempenho preditivo a cada ciclo.\u201d<\/p>\n

Com a expans\u00e3o das colabora\u00e7\u00f5es da Micropep com empresas l\u00edderes como a Corteva e a FMC, a Krisalix est\u00e1 preparada para definir uma nova gera\u00e7\u00e3o de insumos agr\u00edcolas que se destacam pelo desempenho, seguran\u00e7a e escalabilidade.<\/p>\n

\u201cEm \u00faltima an\u00e1lise\u201d, conclui Courbot, \u201ca inova\u00e7\u00e3o em pept\u00eddeos impulsionada por IA levar\u00e1 a agricultura a um futuro mais produtivo, resiliente e sustent\u00e1vel\u201d.\u201d<\/p>","protected":false},"excerpt":{"rendered":"

A tecnologia Micropep Krisalix, impulsionada por intelig\u00eancia artificial, acelera a prote\u00e7\u00e3o biol\u00f3gica de cultivos, promovendo a inova\u00e7\u00e3o sustent\u00e1vel em micropept\u00eddeos para uma agricultura mais segura e resiliente.<\/p>","protected":false},"author":1477,"featured_media":80717,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1917,1604,1786],"tags":[54],"class_list":["post-80714","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abg-update-feature","category-agtech","category-biologicals","tag-featured-home"],"yoast_head":"\nAccelerating the Next Generation of Micropeptide Crop Protection - AgriBusiness Global<\/title>\n<meta name=\"description\" content=\"AI-powered Micropep Krisalix accelerates biological crop protection, driving sustainable micropeptide innovation for safer, more resilient 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