Generic Crop Protection Market Update: 19 Active Ingredients Coming Off Patent by 2028
The generic crop protection market is on the verge of significantly expanding over the next several years. From 2023 to 2028, there will be 19 active ingredients (AIs) that are coming off patent, according to S&P Global. This includes 11 fungicides, four herbicides, and four insecticides. Next year will be especially active in the post-patent market, with 12 AIs expected to be made available following their patent expiry. For the full list of active ingredients coming off patent, in alphabetical order, view the slideshow below.
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1 of 19
Benzovindiflupyr
Patent Expiry: 2028
Inventor: Syngenta AG
Class: Fungicide
Use: Control broad range of fungal diseases-blight, mildew, rust, scab, leafspot on corn, soybean, ornamentals, turf, etc.Source: S&P Global
Photo credit: PubChem -
2 of 19
Bixafen
Patent Expiry: 2023
Inventor: Bayer Crop Science
Class: Fungicide
Use: Broad spectrum fungicide for cereals.Source: S&P Global
Photo credit: PubChem -
3 of 19
Chlorantraniliprole
Patent Expiry: 2024
Inventor: Corteva/FMC
Class: Insecticide
Use: Chewing insects of soybean, F&V, rice, cotton, maize, pome fruit, sugarcane potato, and cereals.Source: S&P Global
Photo credit: PubChem -
4 of 19
Cyantraniliprole
Patent Expiry: 2026
Inventor: Corteva/FMC/Syngenta
Class: Insecticide
Use: Effective against the larval stages of lepidopteran insects; and also on thrips, aphids, and some other chewing and sucking insects on a variety of crops.Source: S&P Global
Photo credit: PubChem -
5 of 19
Flubendiamide
Patent Expiry: 2024
Inventor: Bayer Crop Science
Class: Insecticide
Use: Mainly effective for controlling lepidopteron pests including resistant strain in rice, cotton, corn, grapes, other fruits, and vegetables.Source: S&P Global
Photo credit: PubChem -
6 of 19
Fluopicolide
Patent Expiry: 2024
Inventor: Bayer Crop Science
Class: Fungicide
Use: Fungicide for grapes, potatoes, fruits, and vegetables.Source: S&P Global
Photo credit: PubChem -
7 of 19
Fluopyram
Patent Expiry: 2024
Inventor: Bayer Crop Science
Class: Fungicide
Use: Used against fungal diseases such as gray mold (Botrytis), powdery mildew, apple scab, Alternaria, Sclerotinia, and Monilinia.Source: S&P Global
Photo credit: PubChem -
8 of 19
Isopyrazam
Patent Expiry: 2023
Inventor: Syngenta AG
Class: Fungicide
Use: Broad spectrum fungicide. Controls a wide range of fungal pathogens including Septoria tritici, Puccinia recondita, and Puccinia striformis on wheat; Pyrenophora teres, Rhynchosporium secalis, and Ramularia collocygni on barley; Puccinia recondita on rye; and triticale and Pyrenophora avenae on oats. It also controls Mycospaerella fijiensis on banana.Source: S&P Global
Photo credit: PubChem -
9 of 19
Mandipropamid
Patent Expiry: 2023
Inventor: Syngenta AG
Class: Fungicide
Use: Late blight of potato and tomato. Also used in tobacco, F&V, and vine.Source: S&P Global
Photo credit: PubChem -
10 of 19
Penflufen
Patent Expiry: 2024
Inventor: Bayer Crop Science
Class: Fungicide
Use: Potato: Black Scurf (Rhizoctonia solani), Silver Scurf (Helminthosporium solani), Dry rot (Fusarium spp.). Cereals: Root rot (Rhizoctonia spp.), Smut, (Rape, Soybean, Cotton), and a number of seed-borne pathogens.Source: S&P Global
Photo credit: PubChem -
11 of 19
Penthiopyrad
Patent Expiry: 2024
Inventor: Corteva Agriscience
Class: Fungicide
Use: It offers unique RootingPower that results in stronger, healthier roots for higher crop productivity.Source: S&P Global
Photo credit: PubChem -
12 of 19
Pinoxaden
Patent Expiry: 2026
Inventor: Syngenta AG
Class: Herbicide
Use: Highly selective systemic herbicide used to control monocotyledonous grass weeds in crops such as wild oats, rye-grass, and black grass in winter and spring wheat and winter and spring barley. Controls a broad spectrum of grass weeds in wheat.Source: S&P Global
Photo credit: PubChem -
13 of 19
Pyriofenone
Patent Expiry: 2024
Inventor: Ishihara
Class: Fungicide
Use: Fungicide developed for the control of powdery mildew in cereals and grape vines.Source: S&P Global
Photo credit: PubChem -
14 of 19
Pyroxsulam
Patent Expiry: 2024
Inventor: Corteva Agriscience
Class: Herbicide
Use: Broad spectrum grass and broadleaf weeds of cereals.Source: S&P Global
Photo credit: PubChem -
15 of 19
Saflufenacil
Patent Expiry: 2024
Inventor: BASF
Class: Herbicide
Use: Broadleaf weeds of soybean, maize, sugarcane, cereals, non-crop, and orchards.Source: S&P Global
Photo credit: PubChem -
16 of 19
Sedaxane
Patent Expiry: 2024
Inventor: Syngenta AG
Class: Fungicide
Use: Long-lasting protection against difficult-to-control seed-, soil-, and air-borne pathogens such as: Rhizoctonia spp., Ustilago spp. (on cereals), Tilletia caries, Urocystis occulta, Pyrenophora graminea, Microdochium nivale, Typhula spp., Sphacelotheca reiliana, Macrophomina, Sclerotium spp. and also some activity on Verticillium, Phoma, Helminthosporium solani, Phakopsora, Cochliobolus sativus of cereals, soybeans, canola/oilseed rape, corn, potatoes, rice, sugar beets, cotton, and pulses. It offers unique RootingPower that results in stronger, healthier roots for higher crop productivity.Source: S&P Global
Photo credit: PubChem -
17 of 19
Sulfoxaflor
Patent Expiry: 2027
Inventor: Corteva Agriscience
Class: Insecticide
Use: Sucking pests of turf, soybean, cotton, cereals, and F&V.Source: S&P Global
Photo credit: PubChem -
18 of 19
Thiencarbazone-methyl
Patent Expiry: 2024
Inventor: Bayer Crop Science
Class: Herbicide
Use: Herbicide used for the selective control of grasses and broadleaf weeds primarily in corn.Source: S&P Global
Photo credit: PubChem -
19 of 19
Valifenalate
Patent Expiry: 2024
Inventor: Ishihara
Class: Fungicide
Use: Used to control mildew in many crops including grapes, potatoes, and tomatoes.Source: S&P Global
Photo credit: PubChem
View all
Benzovindiflupyr
Bixafen
Chlorantraniliprole
Cyantraniliprole
Flubendiamide
Fluopicolide
Fluopyram
Isopyrazam
Mandipropamid
Penflufen
Penthiopyrad
Pinoxaden
Pyriofenone
Pyroxsulam
Saflufenacil
Sedaxane
Sulfoxaflor
Thiencarbazone-methyl
Valifenalate
As a result of these pesticides coming off patent, generic manufacturers face a bonanza of market opportunity and the ability to update their portfolios with new chemical technology, particularly in global markets like India.
“The fact that these molecules are going to come out of their patent period will substantially expand the offerings of Indian companies to people at home and abroad alike and may help fetch extra revenue,” said Pradip Dave, Chairman of AIMCO Pesticides Ltd. and President of the Pesticides Manufacturers & Formulators Association of India (PMFAI) in this article in 2021. “The agrochemical sector is deeply interested in the molecules that are going to be off-patented as it creates an opportunity for its own commercial development. Pesticide companies, especially in developing countries, wait for generic active ingredient molecules as it provides huge opportunities for generic manufacturers to provide agrochemicals at a reasonable affordable price for farmers to protect their yield from pests and disease.”
Generic producers constitute about 30% of the global pesticide industry, Pradip said, mainly due to an increase in the number of off-patented molecules and decline in new active ingredients, both of which favor the generic pesticides industry which has seen a faster growth as compared to the inventor or R&D-based companies recently.
An expanded generic crop protection market will also present some challenges for suppliers, says David Li, Marketing Director for SPM Biosciences and author of AgriBusiness Global’s China Price Index.
“In China’s pesticide supply market, the red ocean of competition has turned every supplier into a “prisoner,” wrote Li in a recent column. “The productivity boundaries of the generic active ingredient (AI) (off-patent pesticide) market are being reshaped as global farmers’ willingness to pay decreases and the price of generic products gradually decreases. At the same time, the field of alternatives to generic pesticide products is also squeezing the overall value of the generic AI market.”
Below is a breakdown of active ingredients coming off patent by year. For a more a detailed list, view the slideshow above.
2023
- Bixafen (Bayer Crop Science)
- Isopyrazam (Syngenta AG)
- Mandipropamid (Syngenta AG)
2024
- Chlorantraniliprole (Corteva/FMC)
- Flubendiamide (Bayer Crop Science)
- Fluopicolide (Bayer Crop Science)
- Fluopyram (Bayer Crop Science)
- Penflufen (Bayer Crop Science)
- Penthiopyrad (Corteva Agriscience)
- Pyriofenone (Ishihara)
- Pyroxsulam (Corteva Agriscience)
- Saflufenacil (BASF)
- Sedaxane (Syngenta AG)
- Thiencarbazone-methyl (Bayer Crop Science)
- Valifenalate (Ishihara)
2026
- Cyantraniliprole (Corteva/FMC/Syngenta)
- Pinoxaden (Syngenta AG)
2027
- Sulfoxaflor (Corteva Agriscience)
2028
- Benzovindiflupyr (Syngenta AG)
Source: S&P Global
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Matt Hopkins is Senior Online Editor for the Agribusiness Group at Meister Media Worldwide (MMW), including such brands as CropLife, CropLife IRON, AgriBusiness Global, Global Ag Tech Initiative, and Cotton Grower. He is responsible for managing an array of online products, including newsletters, websites, video, and social media. Hopkins originally joined MMW in 1994 as an editor for Greenhouse Grower magazine before transitioning to Business Manager of its MeisterPro division. He has a Communications Degree from Cleveland State University. See all author stories here.